Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs

Xiaolin Zhang , Gang Liu , Jianbin Yan

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70230

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70230 DOI: 10.1002/ctm2.70230
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Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs

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Xiaolin Zhang,Gang Liu,Jianbin Yan. Paclitaxel biological synthesis promotes the innovation of anti-cancer drugs. Clinical and Translational Medicine, 2025, 15(2): e70230 DOI:10.1002/ctm2.70230

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References

[1]

Horwitz SB. Reflections on my life with Taxol. Cell. 2019; 177(3): 502-505.

[2]

Sofias AM, Dunne M, Storm G, Allen C. The battle of “nano” paclitaxel. Adv Drug Deliv Rev. 2017; 122: 20-30.

[3]

Vitiello A, Ferrara F, Lasala R, Zovi A. Precision medicine in the treatment of locally advanced or metastatic urothelial cancer: new molecular targets and pharmacological therapies. Cancers. 2022; 14(20): 5167.

[4]

Vil V, Terent’ev AO, Al Quntar AAA, Gloriozova TA, Savidov N, Dembitsky VM. Oxetane-containing metabolites: origin, structures, and biological activities. Appl Microbiol Biotechnol. 2019; 103(6): 2449-2467.

[5]

Jiang B, Gao L, Wang H, et al. Characterization and heterologous reconstitution of Taxus biosynthetic enzymes leading to baccatin III. Science. 2024; 383(6683): 622-629.

[6]

Yang C, Wang Y, Su Z, et al. Biosynthesis of the highly oxygenated tetracyclic core skeleton of Taxol. Nat Commun. 2024; 15(1): 2339.

[7]

Xiong X, Gou J, Liao Q, et al. The Taxus genome provides insights into paclitaxel biosynthesis. Nat Plants. 2021; 7(8): 1026-1036.

[8]

Liu JC-T, De La Pena R, Tocol C, Sattely ES. Reconstitution of early paclitaxel biosynthetic network. Nat Commun. 2024; 15(1): 1419.

[9]

Boge TC, Hepperle M, Vander Velde DG, Gunn CW, Grunewald GL, Georg GI. The oxetane conformational lock of paclitaxel: structural analysis of D-secopaclitaxel. Bioorg Med Chem Lett. 1999; 9(20): 3041-3046.

[10]

Rojas JJ, Bull JA. Oxetanes in drug discovery campaigns. J Med Chem. 2023; 66(18): 12697-12709.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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