Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer
Yadong Wang , Qiang Guo , Zhicheng Huang , Liyang Song , Fei Zhao , Tiantian Gu , Zhe Feng , Haibo Wang , Bowen Li , Daoyun Wang , Bin Zhou , Chao Guo , Yuan Xu , Yang Song , Zhibo Zheng , Zhongxing Bing , Haochen Li , Xiaoqing Yu , Ka Luk Fung , Heqing Xu , Jianhong Shi , Meng Chen , Shuai Hong , Haoxuan Jin , Shiyuan Tong , Sibo Zhu , Chen Zhu , Jinlei Song , Jing Liu , Shanqing Li , Hefei Li , Xueguang Sun , Naixin Liang
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70225
Cell-free epigenomes enhanced fragmentomics-based model for early detection of lung cancer
•Our study elucidated the regulatory relationships between epigenetic modifications and their effects on fragmentomic features. | |
•Identifying epigenetically regulated genes provided a critical foundation for developing the cfDNA fragmentomics-based machine learning model. | |
•The model demonstrated exceptional clinical performance, highlighting its substantial potential for translational application in clinical practice. |
cell-free DNA / early cancer screening / epigenomics / liquid biopsy / lung cancer
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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