Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4
Xue-Xue Zhu , Jia-Bao Su , Fang-Ming Wang , Xiao-Ying Chai , Guo Chen , An-Jing Xu , Xin-Yu Meng , Hong-Bo Qiu , Qing-Yi Sun , Yao Wang , Zhuo-Lin Lv , Yuan Zhang , Yao Liu , Zhi-Jun Han , Na Li , Hai-Jian Sun , Qing-Bo Lu
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70221
Sodium pump subunit NKAα1 protects against diabetic endothelial dysfunction by inhibiting ferroptosis through the autophagy-lysosome degradation of ACSL4
•NKAα1 downregulation impairs endothelial function in diabetes by promoting oxidative/nitrative stress and ferroptosis. | |
•NKAα1 supports lysosomal degradation of ACSL4 via autophagy, preventing lipid peroxidation and ferroptosis. | |
•Hamaudol, an activator of NKAα1, restores endothelial relaxation in diabetic mice by inhibiting NKAα1 phosphorylation and endocytosis. |
diabetes / endothelial dysfunction / ferroptosis autophagy / lysosome / oxidative stress
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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