EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway

Keying Li , Changlong Xu , Lulu Liu , Yunjuan Wang , Jun Chen , Chunyuan Li , Zitong Peng , Xiaoqian Li , Gang Chang , Zili Lei , Yanhong Yang

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70219

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70219 DOI: 10.1002/ctm2.70219
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EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway

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Keying Li, Changlong Xu, Lulu Liu, Yunjuan Wang, Jun Chen, Chunyuan Li, Zitong Peng, Xiaoqian Li, Gang Chang, Zili Lei, Yanhong Yang. EpCAM deficiency causes the premature ageing of intestinal stem cells via EGFR/SP1/mTORC1 pathway. Clinical and Translational Medicine, 2025, 15(2): e70219 DOI:10.1002/ctm2.70219

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Lei Z, Chen L, Liu Y, et al. EpCAM deficiency causes premature aging of intestinal epithelium via hyperactivating mTORC1 pathway. Clin Transl Med. 2022; 12(6): e903.

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Zhang Z, Zhang F, Davis AK, et al. CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling. Cell Rep. 2022; 38(2): 110009.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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