Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance

Shengdi Hou; Jing Zhang; Zhiqiang Zhang; Hong Qu; Shuhong Li; Ying Jiang; Chongdong Liu

doi:10.1002/ctm2.70216

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70216 DOI: 10.1002/ctm2.70216

RESEARCH ARTICLE

Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance

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Abstract

	•Single-cell RNA (ScRNA) atlas across types of endometriosis is established.
	•Mesothelial cells are founded in ovarian endometriosis.
	•Endometriosis-associated mesothelial cells (EAMCs) experience various level of epithelial–mesenchymal transition (EMT) process in different subtypes.
	•EAMCs may exert an influence on progesterone resistance in stromal cells through intercellular communication mediated by the FN1-AKT pathway.

Keywords

endometriosis / epithelial–mesenchymal transition / FN1-AKT pathway / mesothelial cells / progesterone resistance / single-cell RNA sequence

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Shengdi Hou, Jing Zhang, Zhiqiang Zhang, Hong Qu, Shuhong Li, Ying Jiang, Chongdong Liu. Single-cell transcriptomic atlas of different endometriosis indicating that an interaction between endometriosis-associated mesothelial cells (EAMCs) and ectopic stromal cells may influence progesterone resistance. Clinical and Translational Medicine, 2025, 15(2): e70216 DOI:10.1002/ctm2.70216

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.