Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis

Abstract

	•Chaperone-mediated autophagy (CMA) deficiency in hepatocytes promotes hepatic inflammation and fibrosis in mice with nonalcoholic steatohepatitis (NASH) by inducing cholesterol accumulation and endoplasmic reticulum (ER) stress.
	•Upregulated FOXM1 impairs CMA by suppressing the transcription of lysosome-associated membrane protein 2A (LAMP2A), a rate-limiting component of CMA.
	•ER stress increases FOXM1 expression and cholesterol accumulation.
	•FOXM1/CMA/ER stress axis forms a vicious circle and promotes the development of NASH.

Keywords

chaperone-mediated autophagy / cholesterol / endoplasmic reticulum stress / FOXM1 / nonalcoholic steatohepatitis

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.