Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis
Shuoyi Ma , Erzhuo Xia , Miao Zhang , Yinan Hu , Siyuan Tian , Xiaohong Zheng , Bo Li , Gang Ma , Rui Su , Keshuai Sun , Qingling Fan , Fangfang Yang , Guanya Guo , Changcun Guo , Yulong Shang , Xinmin Zhou , Xia Zhou , Jingbo Wang , Ying Han
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70202
Role of the FOXM1/CMA/ER stress axis in regulating the progression of nonalcoholic steatohepatitis
| •Chaperone-mediated autophagy (CMA) deficiency in hepatocytes promotes hepatic inflammation and fibrosis in mice with nonalcoholic steatohepatitis (NASH) by inducing cholesterol accumulation and endoplasmic reticulum (ER) stress. | |
| •Upregulated FOXM1 impairs CMA by suppressing the transcription of lysosome-associated membrane protein 2A (LAMP2A), a rate-limiting component of CMA. | |
•ER stress increases FOXM1 expression and cholesterol accumulation. | |
•FOXM1/CMA/ER stress axis forms a vicious circle and promotes the development of NASH. |
chaperone-mediated autophagy / cholesterol / endoplasmic reticulum stress / FOXM1 / nonalcoholic steatohepatitis
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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