Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease

Xiaofang Zhao; Senyan Wang; Qi Liu; Wenjuan Wei; Xiaoyan Sun; Hao Song; Jing Xu; Shuijun Zhang; Hongyang Wang; Jing Fu

doi:10.1002/ctm2.70198

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70198 DOI: 10.1002/ctm2.70198

RESEARCH ARTICLE

Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease

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Abstract

	•This study provides single-cell landscape of human liver samples across different ALD stages.
	•The ALB⁺ KRT7⁺ epithelium were enriched in ALD patients, and the function of this epithelial population varied significantly across ALD stages.
	•ALB⁺KRT7⁺ epithelium from advanced alcohol-related cirrhosis had malignant transformation potential and tumour promotion activity.
	•The comprehensive changes of parenchymal and nonparenchymal cells in the ALD livers lay a hidden danger for the further malignant progression.、

Keywords

ALB ⁺KRT7 ⁺ epithelium / alcohol-related liver disease / single-cell RNA-seq / Wnt/β-catenin

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Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu. Single-cell landscape of the intrahepatic ecosystem in alcohol-related liver disease. Clinical and Translational Medicine, 2025, 15(1): e70198 DOI:10.1002/ctm2.70198

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.