Vitamin K-dependent gamma-carboxyglutamic acid protein 1 promotes pancreatic ductal adenocarcinoma progression through stabilizing oncoprotein KRAS and tyrosine kinase receptor EGFR

Abstract

	•PRRG1 is identified as the transmembrane Gla protein mediating PDAC malignancy.
	•PRRG1 recruits and induces self-ubiquitination of membrane-anchoring E3 ligase NEDD4.
	•PRRG1 exerts a protective role toward KRAS and EGFR by inhibiting NEDD4.
	•The anticoagulant warfarin can be utilized to inhibit PRRG1 and PDAC advancement.

Keywords

KRAS / NEDD4 E3 ligases / pancreatic cancer / PRRG1 / vitamin K-dependent carboxylation

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.