Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1

Cunru Zou , Yu Zhang , Chengyue Liu , Yaxin Li , Congjie Lin , Hao Chen , Jiangping Hou , Guojun Gao , Zheng Liu , Qiupeng Yan , Wenxia Su

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70182

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Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70182 DOI: 10.1002/ctm2.70182
RESEARCH ARTICLE

Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1

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Abstract

CENPM is the key gene that drives ACC metastasis, and a robust biomarker for ACC prognosis.

•Silencing CENPM impedes ACC metastasis in vitro and in vivo by physical interaction with immune checkpoint ligand FGL1.

•FGL1 is overexpressed in ACC and promotes ACC metastasis.

Keywords

adrenocortical carcinoma / CENPM / FGL1 / metastasis

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Cunru Zou,Yu Zhang,Chengyue Liu,Yaxin Li,Congjie Lin,Hao Chen,Jiangping Hou,Guojun Gao,Zheng Liu,Qiupeng Yan,Wenxia Su. Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1. Clinical and Translational Medicine, 2025, 15(1): e70182 DOI:10.1002/ctm2.70182

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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