Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1
Cunru Zou , Yu Zhang , Chengyue Liu , Yaxin Li , Congjie Lin , Hao Chen , Jiangping Hou , Guojun Gao , Zheng Liu , Qiupeng Yan , Wenxia Su
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70182
Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1
•CENPM is the key gene that drives ACC metastasis, and a robust biomarker for ACC prognosis. | |
•Silencing CENPM impedes ACC metastasis in vitro and in vivo by physical interaction with immune checkpoint ligand FGL1. | |
•FGL1 is overexpressed in ACC and promotes ACC metastasis. |
adrenocortical carcinoma / CENPM / FGL1 / metastasis
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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