CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis

YaoMing Zheng; YaDong Xie; JiaYing Li; YuJie Cao; Min Li; Qing Cao; MiaoMiao Han; HongFei Lou; YiLai Shu; Hui Xiao; HuaBin Li

doi:10.1002/ctm2.70180

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70180 DOI: 10.1002/ctm2.70180

RESEARCH ARTICLE

CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis

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Abstract

	•Cytidine/uridine monophosphate kinase 2 (CMPK2) expression is up-regulated in the nasal mucosa of patients and mice with allergic rhinitis (AR).
	•CMPK2 caused NLRP3 inflammasome activation via mitochondrial DNA (mtDNA)-STING pathway.
	•Blocking CMPK2 or STING signalling significantly reduced the activation of NLRP3 in house dust mite (HDM)-challenged mice and human nasal epithelial cells (HNEPCs).

Keywords

allergic rhinitis / CMPK2 / mitochondrial DNA / NLRP3 inflammasome / STING

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YaoMing Zheng, YaDong Xie, JiaYing Li, YuJie Cao, Min Li, Qing Cao, MiaoMiao Han, HongFei Lou, YiLai Shu, Hui Xiao, HuaBin Li. CMPK2 promotes NLRP3 inflammasome activation via mtDNA-STING pathway in house dust mite-induced allergic rhinitis. Clinical and Translational Medicine, 2025, 15(1): e70180 DOI:10.1002/ctm2.70180

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.