Annexin A8 deficiency delays atherosclerosis progression
Carmen Gutiérrez-Muñoz , Rafael Blázquez-Serra , Irene San Sebastián-Jaraba , Sandra Sanz-Andrea , Maria J. Fernández-Gómez , Gonzalo Nuñez-Moreno , Pablo Mínguez , Joan Carles Escolá-Gil , Paula Nogales , Veronique Ollivier , Jose L. Martín-Ventura , Benoit Ho-Tin-Noe , Ursula Rescher , Nerea Méndez-Barbero , Luis M. Blanco-Colio
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70176
Annexin A8 deficiency delays atherosclerosis progression
•This study shows that AnxA8 is upregulated in aorta of atheroprone mice and in human atherosclerotic plaques. | |
•Germline AnxA8 deficiency reduces platelet and leukocyte recruitment to activated endothelium as well as atherosclerotic burden, plaque size, and macrophage accumulation in mice. | |
•AnxA8 regulates oxLDL-induced adhesion molecules expression in aortic endothelial cells. Our data strongly suggest that AnxA8 promotes disease progression through regulation of adhesion and influx of immune cells to the intima. | |
•Endothelial specific silencing of AnxA8 reduced atherosclerosis progression. | |
•Therapeutic interventions to reduce AnxA8 expression may delay atherosclerosis progression. |
AnxA8 / atherosclerosis / inflammation
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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