Annexin A8 deficiency delays atherosclerosis progression

Abstract

	•This study shows that AnxA8 is upregulated in aorta of atheroprone mice and in human atherosclerotic plaques.
	•Germline AnxA8 deficiency reduces platelet and leukocyte recruitment to activated endothelium as well as atherosclerotic burden, plaque size, and macrophage accumulation in mice.
	•AnxA8 regulates oxLDL-induced adhesion molecules expression in aortic endothelial cells. Our data strongly suggest that AnxA8 promotes disease progression through regulation of adhesion and influx of immune cells to the intima.
	•Endothelial specific silencing of AnxA8 reduced atherosclerosis progression.
	•Therapeutic interventions to reduce AnxA8 expression may delay atherosclerosis progression.

Keywords

AnxA8 / atherosclerosis / inflammation

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.