Immunoregulatory programs in anti-N-methyl-D-aspartate receptor encephalitis identified by single-cell multi-omics analysis

Abstract

	•Significant B cell clonal expansion, particularly in plasma cells, driven by antigen recognition.
	•IFN-I pathway activation in plasma cells boosts their antibody production and potentially exacerbates immune dysregulation.
	•TLR2 pathway activation in myeloid cells contributes to TNF-α secretion and could influence adaptive immune responses.

Keywords

anti- N-methyl-D-aspartate receptor encephalitis / autoimmune disease / regulatory program / single-cell multi-omics sequencing

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.