EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B

Yuyang Zhang; Mingqin Su; Yiming Chen; Li Cui; Wei Xia; Renfang Xu; Dong Xue; Xiansheng Zhang; Xingliang Feng

doi:10.1002/ctm2.70164

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70164 DOI: 10.1002/ctm2.70164

RESEARCH ARTICLE

EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B

Yuyang Zhang ¹^,²^,³
, Mingqin Su ⁴
, Yiming Chen ⁵^,⁶
, Li Cui ⁵^,⁶
, Wei Xia ⁵^,⁶
, Renfang Xu ⁵^,⁶
, Dong Xue ⁵^,⁶^,^†
, Xiansheng Zhang ¹^,²^,³^,^†
, Xingliang Feng ⁵^,⁶^,^†

Author information +

History +

PDF

Abstract

	•Euchromatic histone lysine methyltransferase 2 (EHMT2) is overexpressed in advanced prostate cancer, restraining catastrophic chromosomal instability (CIN) and enhancing cell fitness.
	•EHMT2 functions via the centromeric R-loop-driven ATR–CHK1–Aurora B pathway to promote chromosomal stability.
	•EHMT2 confers enzalutamide resistance via activating Aurora B.
	•Cullin 3 (CUL3) promotes EHMT2 destabilisation via deubiquitination.

Keywords

Aurora B / CIN / CUL3 / EHMT2

Cite this article

Download citation ▾

Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng. EHMT2-mediated R-loop formation promotes the malignant progression of prostate cancer via activating Aurora B. Clinical and Translational Medicine, 2025, 15(1): e70164 DOI:10.1002/ctm2.70164

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.