A new peptide inhibitor of C1QBP exhibits potent anti-tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair
Xingxing Li , Yue Wu , Min Zhang , Fengliang Wang , Hong Yin , Yanrong Zhang , Shuli Zhao , Jiehua Ma , Mingming Lv , Cheng Lu
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70162
A new peptide inhibitor of C1QBP exhibits potent anti-tumour activity against triple negative breast cancer by impairing mitochondrial function and suppressing homologous recombination repair
•The newly discovered peptide PDBAG1 is the first small molecule substance found to directly target and degrade C1QBP, demonstrating significant tumour inhibitory effects and therapeutic potential. |
anti-tumour peptide / C1QBP / homologous recombination repair / mitochondrial function / targeted protein degradation
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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