LcProt: Proteomics-based identification of plasma biomarkers for lung cancer multievent, a multicentre study
Hengrui Liang , Runchen Wang , Ran Cheng , Zhiming Ye , Na Zhao , Xiaohong Zhao , Ying Huang , Zhanpeng Jiang , Wangzhong Li , Jianqi Zheng , Hongsheng Deng , Yu Jiang , Yuechun Lin , Yun Yan , Lei Song , Jie Li , Xin Xu , Wenhua Liang , Jun Liu , Jianxing He
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70160
LcProt: Proteomics-based identification of plasma biomarkers for lung cancer multievent, a multicentre study
•Our study developed an innovative nanomaterial, Zeolite NaY, which addressed the masking effect and improved the depth of the proteome. | |
•The performance of NaY-based plasma proteomics as a preclinical diagnostic tool was validated through both internal and external cohort. | |
| •Furthermore, we explored the different patterns of plasma protein changes during the progression of lung cancer and used the explanations method to elucidate the roles of proteins in the multitask predictive model. |
lung cancer / multitask / plasma proteomics / zeolite NaY
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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