Single-cell transcriptomics and metabolomic analysis reveal adenosine-derived metabolites over-representation in pseudohypoxic neuroendocrine tumours

Yuval Kahan Yossef , Liav Sela Peremen , Alona Telerman , Gil Goldinger , Sergey Malitsky , Maxim Itkin , Reut Halperin , Naama Peshes Yaloz , Amit Tirosh

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70159

PDF
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (2) : e70159 DOI: 10.1002/ctm2.70159
LETTER TO THE JOURNAL

Single-cell transcriptomics and metabolomic analysis reveal adenosine-derived metabolites over-representation in pseudohypoxic neuroendocrine tumours

Author information +
History +
PDF

Cite this article

Download citation ▾
Yuval Kahan Yossef, Liav Sela Peremen, Alona Telerman, Gil Goldinger, Sergey Malitsky, Maxim Itkin, Reut Halperin, Naama Peshes Yaloz, Amit Tirosh. Single-cell transcriptomics and metabolomic analysis reveal adenosine-derived metabolites over-representation in pseudohypoxic neuroendocrine tumours. Clinical and Translational Medicine, 2025, 15(2): e70159 DOI:10.1002/ctm2.70159

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Lonser RR, Glenn GM, Walther M, et al. von Hippel−Lindau disease. Lancet. 2003; 361(9374): 2059-2067.

[2]

Buckley M, Terwagne C, Ganner A, et al. Saturation genome editing maps the functional spectrum of pathogenic VHL alleles. Nat Genet. 2024; 56(7): 1446-1455.

[3]

Jaakkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel−Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001; 292(5516): 468-472.

[4]

Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999; 399(6733): 271-275.

[5]

Wicks EE, Semenza GL. Hypoxia-inducible factors: cancer progression and clinical translation. J Clin Invest. 2022; 132(11): e159839.

[6]

Kierans SJ, Taylor CT. Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol. 2021; 599(1): 23-37.

[7]

Warburg O, Wind F, Negelein E. The metabolism of tumors in the human body. J Gen Physiol. 1927; 8(6): 519-530. http://www.ncbi.nlm.nih.gov/pubmed/19872213

[8]

Scarpa A, Chang DK, Nones K, et al. Whole-genome landscape of pancreatic neuroendocrine tumours. Nature. 2017; 543(7643): 65-71. doi:10.1038/nature21063

[9]

Pacini ESA, Satori NA, Jackson EK, Godinho RO. Extracellular cAMP-adenosine pathway signaling: a potential therapeutic target in chronic inflammatory airway diseases. Front Immunol. 2022; 13: 866097.

RIGHTS & PERMISSIONS

2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

AI Summary AI Mindmap
PDF

109

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/