Unravelling the prognostic and operative role of intratumoural microbiota in non-small cell lung cancer: Insights from 16S rRNA and RNA sequencing
Fuling Mao , Zixuan Hu , Ruifeng Shi , Hongbing Zhang , Zihe Zhang , Yongwen Li , Xuanguang Li , Penghu Gao , Jinhui Li , Minghui Liu , Hongyu Liu , Jun Chen
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70156
Unravelling the prognostic and operative role of intratumoural microbiota in non-small cell lung cancer: Insights from 16S rRNA and RNA sequencing
•Four phyla, five classes, nine orders, 17 families and 36 genera have been found associated with NSCLC prognosis. | |
•We identified a protective microbial cluster associated with delayed recurrence and a harmful microbial cluster related to shorter survival and earlier recurrence. | |
•We identified Peptococcus as an independent, detrimental prognostic factor for NSCLC, potentially impacting prognosis via TNF signalling. |
microbiota / non-small cell lung cancer (NSCLC) / Peptococcus / prognosis / protective and harmful microbial clusters
2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
/
| 〈 |
|
〉 |
PDF
