Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR-mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis

Abstract

	•The combination regimen yielded promising efficacy in NSCLC patients after EGFR-TKI resistance, particularly those with PD-L1-positive tumours.
	•Higher peritumour NK cell and lower peripheral helper T cell were associated with favourable ORR and longer PFS, respectively.
	•After disease progression, the proportion of S100A9+ MDSC increased, but Treg cells decreased.

Keywords

anti-angiogenesis / atezolizumab / EGFR TKI resistance / immune cell / tumour microenvironment

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.