Deficiency of ATF3 facilitates both angiotensin II-induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway
Yifan Du , Poyi Hu , Xiangchao Ding , Dashuai Wang , Jingjing Luo , Sheng Le , Lingyun Ren , Manhua Chen , Ping Ye , Jiahong Xia
Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70147
Deficiency of ATF3 facilitates both angiotensin II-induced and spontaneously formed aortic aneurysm and dissection development by activating cGAS–STING pathway
•ATF3 deficiency led to degradation of P21 through ubiquitination, which abolished the G1 phase arrest. | |
•VSMCs had no time window to repair the damaged DNA, leading to generation of micronuclei in cytoplasm. | |
•Cytoplasmic micronuclei facilitating the activation of cGAS–STING pathway, thus inducing the phenotypic switch and apoptosis of VSMCs |
aortic aneurysm and dissection / cGAS–STING pathway / DNA stability / micronuclei formation / P21
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
/
| 〈 |
|
〉 |
PDF
