Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury

Abstract

	•During intestinal ischaemia, mitochondrial oxygen uptake is reduced when cellular oxygen partial pressure decreases to below the threshold required to maintain normal oxidative metabolism.
	•Upon reperfusion, intestinal hypoxia may persist because microcirculatory flow remains impaired and/or because available oxygen is consumed by enzymes, intestinal cells and neutrophils.

Keywords

dysoxia / hypoxia / intestine / ischaemia–reperfusion injury / oxygen

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