Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury

Paraschos Archontakis-Barakakis; Theodoros Mavridis; David-Dimitris Chlorogiannis; Georgios Barakakis; Eleni Laou; Daniel I. Sessler; George Gkiokas; Athanasios Chalkias

doi:10.1002/ctm2.70136

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70136 DOI: 10.1002/ctm2.70136

REVIEW

Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury

Author information +

History +

PDF

Abstract

	•During intestinal ischaemia, mitochondrial oxygen uptake is reduced when cellular oxygen partial pressure decreases to below the threshold required to maintain normal oxidative metabolism.
	•Upon reperfusion, intestinal hypoxia may persist because microcirculatory flow remains impaired and/or because available oxygen is consumed by enzymes, intestinal cells and neutrophils.

Keywords

dysoxia / hypoxia / intestine / ischaemia–reperfusion injury / oxygen

Cite this article

Download citation ▾

Paraschos Archontakis-Barakakis,Theodoros Mavridis,David-Dimitris Chlorogiannis,Georgios Barakakis,Eleni Laou,Daniel I. Sessler,George Gkiokas,Athanasios Chalkias. Intestinal oxygen utilisation and cellular adaptation during intestinal ischaemia–reperfusion injury. Clinical and Translational Medicine, 2025, 15(1): e70136 DOI:10.1002/ctm2.70136

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

RIGHTS & PERMISSIONS

2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.