Deciphering the epigenetic role of long non-coding RNAs in mood disorders: Focus on human brain studies

Bhaskar Roy; Anuj K. Verma; Yu Funahashi; Yogesh Dwivedi

doi:10.1002/ctm2.70135

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70135 DOI: 10.1002/ctm2.70135

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Deciphering the epigenetic role of long non-coding RNAs in mood disorders: Focus on human brain studies

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Abstract

	•Brain-centric lncRNAs regulate gene networks, and their disruption is linked to MDD.
	•In MDD, altered lncRNAs disrupt gene regulation by changing chromatin looping or modifying chromatin accessibility.
	•These changes lead to neuronal dysfunction, affecting neural circuitry and synaptic plasticity.
	•The result is impaired brain function, contributing to the symptoms of MDD.

Keywords

bipolar disorder / epigenetics / gene regulation / human postmortem brain / long non-coding RNA / major depressive disorder

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Bhaskar Roy,Anuj K. Verma,Yu Funahashi,Yogesh Dwivedi. Deciphering the epigenetic role of long non-coding RNAs in mood disorders: Focus on human brain studies. Clinical and Translational Medicine, 2025, 15(3): e70135 DOI:10.1002/ctm2.70135

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.