Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling

Brendan J. Keating; Eloi Schmauch; Michael P. Snyder; Jennifer D. Motter; Brian D. Piening

doi:10.1002/ctm2.70132

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (1) : e70132 DOI: 10.1002/ctm2.70132

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Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling

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Brendan J. Keating, Eloi Schmauch, Michael P. Snyder, Jennifer D. Motter, Brian D. Piening. Commentary: Molecular responses in pig heart to human xenotransplantation unveiled by longitudinal multi-omic profiling. Clinical and Translational Medicine, 2025, 15(1): e70132 DOI:10.1002/ctm2.70132

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References

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[1]	Jou S, Mendez SR, Feinman J, et al. Heart transplantation: advances in expanding the donor pool and xenotransplantation. Nat Rev Cardiol. 2024;21(1):25-36.

[2]	Colvin MM, Smith JM, Ahn YS, et al. OPTN/SRTR 2022 Annual Data Report: heart. Am J Transplant. 2024;24(2S1):S305-S393.

[3]	Montgomery RA, Stern JM, Lonze BE, et al. Results of two cases of pig-to-human kidney xenotransplantation. N Engl J Med. 2022;386(20):1889-1898.

[4]	Hryhorowicz M, Zeyland J, Slomski R, Lipinski D. Genetically modified pigs as organ donors for xenotransplantation. Mol Biotechnol. 2017;59(9-10):435-444.

[5]	Cooper DK. A brief history of cross-species organ transplantation. Proc (Bayl Univ Med Cent). 2012;25(1):49-57.

[6]	Moazami N, Stern JM, Khalil K, et al. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nat Med. 2023;29(8):1989-1997.

[7]	Schmauch E, Piening B, Mohebnasab M, et al. Integrative multi-omics profiling in human decedents receiving pig heart xenografts. Nat Med. 2024;30(5):1448-1460.

[8]	Baysoy A, Bai Z, Satija R, Fan R. The technological landscape and applications of single-cell multi-omics. Nat Rev Mol Cell Biol. 2023;24(10):695-713.

[9]	Byrne GW, McGregor CG. Cardiac xenotransplantation: progress and challenges. Curr Opin Organ Transplant. 2012;17(2):148-154.

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2025 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.