Epithelial NSD2 maintains FMO-mediated taurine biosynthesis to prevent intestinal barrier disruption
Yue Xu , Xiuying Xiao , Chunxiao Ma , Ziyi Wang , Wenxin Feng , Hanyu Rao , Wei Zhang , Ningyuan Liu , Rebiguli Aji , Xiangjun Meng , Wei-Qiang Gao , Li Li
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70128
Epithelial NSD2 maintains FMO-mediated taurine biosynthesis to prevent intestinal barrier disruption
•In this study, we investigated the role of the histone methyltransferase NSD2 in preventing intestinal barrier disruption by sustaining taurine biosynthesis. NSD2 levels were reduced in both human specimens and mouse models of IBD. We demonstrate that NSD2 loss hinders the process of taurine synthesis in intestinal cells, leading to increased intestinal inflammation. | |
•Supplementation with taurine significantly relieved the symptoms caused by NSD2 deficiency. These data suggest that maintenance of NSD2-mediated taurine biosynthesis is vital for preserving the intestinal barrier and attenuating inflammation. |
histone methylation / IBD / intestinal epithelial homeostasis / NSD2 / taurine biosynthesis
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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