Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediatedmicroglia underlies a therapy for intracerebral hemorrhage

Wenqiao Qiu; Jie Tian; Gao Mou; Lili Guo; Tao Xu; Wei Liu; Jianwei Zhu; Yi Zhang; Xiaolin Hou; Yao Xie; Huan Xiong; Xinda Li; Yangyang Wang; Mingjun Gao; Anguo Wu; Longyi Chen; Jie Mei; Lulin Huang; Ruxiang Xu

doi:10.1002/ctm2.70127

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70127 DOI: 10.1002/ctm2.70127

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Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediatedmicroglia underlies a therapy for intracerebral hemorrhage

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¹. Department of Neurosurgery, Sichuan Provincial People’sHospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China

². Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China

³. Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Department of Mechanical Engineering, Tsinghua University, Beijing, People’s Republic of China

⁴. Department of Obstetrics & Gynecology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

⁵. Sichuan Key Medical Laboratory of New Drug Discovery and Drugability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, School of Preclinical Medicine, Key Laboratory of Medical Electrophysiology of Ministry of Education; School of Pharmacy, Southwest Medical University, Luzhou, China

⁶. Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics, Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

⁷. Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, China

meijie@med.uestc.edu.cn

huangluling@yeah.net

xuruxiang1123@uestc.edu.cn

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Wenqiao Qiu, Jie Tian, Gao Mou, Lili Guo, Tao Xu, Wei Liu, Jianwei Zhu, Yi Zhang, Xiaolin Hou, Yao Xie, Huan Xiong, Xinda Li, Yangyang Wang, Mingjun Gao, Anguo Wu, Longyi Chen, Jie Mei, Lulin Huang, Ruxiang Xu. Spatiotemporal transcriptome and scRNA sequencing analysis reveals that IKFZ1-mediatedmicroglia underlies a therapy for intracerebral hemorrhage. Clinical and Translational Medicine, 2024, 14(12): e70127 DOI:10.1002/ctm2.70127

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.