Glucose-induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma

Yanfang Liu; Junjiao Song; Qili Shi; Bing Chen; Wenying Qiu; Yizhe Liu; Shenglin Huang; Xianghuo He

doi:10.1002/ctm2.70122

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70122 DOI: 10.1002/ctm2.70122

RESEARCH ARTICLE

Glucose-induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma

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Abstract

	•This study highlights the considerable regulatory role of LINC01419 in the metabolism of HCC.
	•The newly identified LINC01419/YBX1-PDK1 axis constitutes a valuable target.
	•Hepatic-specific delivery of GalNAc-siLINC01419 presents a promising therapeutic strategy for HCC.

Keywords

glycolytic pathway / hepatocellular carcinoma / LINC01419 / mRNA stability / PDK1

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Yanfang Liu,Junjiao Song,Qili Shi,Bing Chen,Wenying Qiu,Yizhe Liu,Shenglin Huang,Xianghuo He. Glucose-induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma. Clinical and Translational Medicine, 2024, 14(12): e70122 DOI:10.1002/ctm2.70122

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.