Corticostriatal glutamate-mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model

Abstract

	•EA commonly protects dopaminergic neuronsby reducing neuroinflammation, oxidative stress, and apoptosis.
	•New findings reveal that EA alleviates motor symptoms in a parkinsonian rat model without restoring striatal dopamine levels.
	•EA effectively suppresses excessiveglutamate transmission and high-beta synchronization, contributing to motorsymptom relief.
	•Activation of corticostriatalglutamatergic projections may hinder the efficacy of EA.

Keywords

beta oscillatory synchrony / corticostriatal glutamate transmission / electroacupuncture stimulation / Parkinson’s disease

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RIGHTS & PERMISSIONS

2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.