Corticostriatal glutamate-mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model

Xinxin Jiang; Min Sun; Yitong Yan; Yanhua Wang; Xinyu Fan; Jing Wei; Ke Wang; Peirong Liang; Zirui Wang; Jihan Wang; Xiaomin Wang; Jun Jia

doi:10.1002/ctm2.70117

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70117 DOI: 10.1002/ctm2.70117

RESEARCH ARTICLE

Corticostriatal glutamate-mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model

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Abstract

	•EA commonly protects dopaminergic neuronsby reducing neuroinflammation, oxidative stress, and apoptosis.
	•New findings reveal that EA alleviates motor symptoms in a parkinsonian rat model without restoring striatal dopamine levels.
	•EA effectively suppresses excessiveglutamate transmission and high-beta synchronization, contributing to motorsymptom relief.
	•Activation of corticostriatalglutamatergic projections may hinder the efficacy of EA.

Keywords

beta oscillatory synchrony / corticostriatal glutamate transmission / electroacupuncture stimulation / Parkinson’s disease

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Xinxin Jiang, Min Sun, Yitong Yan, Yanhua Wang, Xinyu Fan, Jing Wei, Ke Wang, Peirong Liang, Zirui Wang, Jihan Wang, Xiaomin Wang, Jun Jia. Corticostriatal glutamate-mediated dynamic therapeutic efficacy of electroacupuncture in a parkinsonian rat model. Clinical and Translational Medicine, 2024, 14(12): e70117 DOI:10.1002/ctm2.70117

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.