Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell RNA sequencing

Jingyuan Huo , Zhen Wang , Wenting Zhao , Miao Chen , Haoyang Li , Fengpu He , Xiao Tian , Yaqi Ma , Firyuza Husanova , Liang Ma , Yiming Ni , Hongda Ding , Weidong Li , Hongfei Xu

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70113

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70113 DOI: 10.1002/ctm2.70113
RESEARCH ARTICLE

Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell RNA sequencing

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Abstract

•Insights into the heterogeneity and transcriptional patterns of sarcoma cells may explain the challenges in treating primary cardiac angiosarcoma (PCAS) using the current therapeutic modalities.

•Characterization of the immune microenvironment revealed significant immunosuppression mediated by specific myeloid cell populations (SPP1+ and OLR1+ macrophages).

•Identification of mitochondrial dysfunction in immune cells within the PCAS microenvironment, particularly the notable downregulation of the MTRNR2L12 protein, suggests a new avenue for therapeutic targeting.

Keywords

heterogeneity / multicolour immunohistochemistry / primary cardiac angiosarcoma / single-cell RNA sequencing / tumour microenvironment

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Jingyuan Huo,Zhen Wang,Wenting Zhao,Miao Chen,Haoyang Li,Fengpu He,Xiao Tian,Yaqi Ma,Firyuza Husanova,Liang Ma,Yiming Ni,Hongda Ding,Weidong Li,Hongfei Xu. Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell RNA sequencing. Clinical and Translational Medicine, 2024, 14(12): e70113 DOI:10.1002/ctm2.70113

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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