Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell RNA sequencing
Jingyuan Huo , Zhen Wang , Wenting Zhao , Miao Chen , Haoyang Li , Fengpu He , Xiao Tian , Yaqi Ma , Firyuza Husanova , Liang Ma , Yiming Ni , Hongda Ding , Weidong Li , Hongfei Xu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70113
Investigating intra-tumoural heterogeneity and microenvironment diversity in primary cardiac angiosarcoma through single-cell RNA sequencing
•Insights into the heterogeneity and transcriptional patterns of sarcoma cells may explain the challenges in treating primary cardiac angiosarcoma (PCAS) using the current therapeutic modalities. | |
•Characterization of the immune microenvironment revealed significant immunosuppression mediated by specific myeloid cell populations (SPP1+ and OLR1+ macrophages). | |
•Identification of mitochondrial dysfunction in immune cells within the PCAS microenvironment, particularly the notable downregulation of the MTRNR2L12 protein, suggests a new avenue for therapeutic targeting. |
heterogeneity / multicolour immunohistochemistry / primary cardiac angiosarcoma / single-cell RNA sequencing / tumour microenvironment
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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