Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus

Heming Ge; Zhengda Pei; Zhongyi Zhou; Qian Pei; Cenap Güngör; Linyi Zheng; Wei Liu; Fengyuan Li; Jingxuan Zhou; Yao Xiang; Haiping Pei; Yuqiang Li; Wenxue Liu

doi:10.1002/ctm2.70112

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70112 DOI: 10.1002/ctm2.70112

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Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus

Heming Ge ¹^,²^,³
, Zhengda Pei ⁴
, Zhongyi Zhou ¹^,²
, Qian Pei ¹^,²
, Cenap Güngör ³
, Linyi Zheng ¹^,²
, Wei Liu ¹^,²
, Fengyuan Li ¹^,²
, Jingxuan Zhou ⁵
, Yao Xiang ⁶
, Haiping Pei ¹^,²
, Yuqiang Li ¹^,²^,^†
, Wenxue Liu ²^,⁷^,^†

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Heming Ge, Zhengda Pei, Zhongyi Zhou, Qian Pei, Cenap Güngör, Linyi Zheng, Wei Liu, Fengyuan Li, Jingxuan Zhou, Yao Xiang, Haiping Pei, Yuqiang Li, Wenxue Liu. Spatial transcriptomics deciphers the immunosuppressive microenvironment in colorectal cancer with tumour thrombus. Clinical and Translational Medicine, 2024, 14(12): e70112 DOI:10.1002/ctm2.70112

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References

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[1]	Argiles G, Tabernero J, Labianca R, et al. Localised colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2020; 31(10): 1291-1305.

[2]	Park SS, Lee YK, Choi YW, et al. Cellular senescence is associated with the spatial evolution toward a higher metastatic phenotype in colorectal cancer. Cell Rep. 2024; 43(3): 113912.

[3]	Patel AP, Tirosh I, Trombetta JJ, et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science. 2014; 344(6190): 1396-1401.

[4]	Lee HO, Hong Y, Etlioglu HE, et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet. 2020; 52(6): 594-603.

[5]	Jiang P, Gu S, Pan D, et al. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018; 24(10): 1550-1558.

[6]	Jin S, Guerrero-Juarez CF, Zhang L, et al. Inference and analysis of cell-cell communication using CellChat. Nat Commun. 2021; 12(1): 1088.

[7]	Li K, Zhang R, Wen F, et al. Single-cell dissection of the multicellular ecosystem and molecular features underlying microvascular invasion in HCC. Hepatology. 2024; 79(6): 1293-1309.

[8]	Marisa L, de Reynies A, Duval A, et al. Gene expression classification of colon cancer into molecular subtypes: characterization, validation, and prognostic value. PLoS Med. 2013; 10(5): e1001453.

[9]	Tripathi MK, Deane NG, Zhu J, et al. Nuclear factor of activated T-cell activity is associated with metastatic capacity in colon cancer. Cancer Res. 2014; 74(23): 6947-6957.

[10]	Newman AM, Liu CL, Green MR, et al. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015; 12(5): 453-457.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.