A vital step determines the quality of human eggs: Spindle bipolarization

Tianyu Wu; Yuxi Luo; Lei Wang; Qing Sang

doi:10.1002/ctm2.70109

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70109 DOI: 10.1002/ctm2.70109

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A vital step determines the quality of human eggs: Spindle bipolarization

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Tianyu Wu, Yuxi Luo, Lei Wang, Qing Sang. A vital step determines the quality of human eggs: Spindle bipolarization. Clinical and Translational Medicine, 2024, 14(12): e70109 DOI:10.1002/ctm2.70109

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References

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[1]	Bennabi I, Terret ME, Verlhac MH. Meiotic spindle assembly and chromosome segregation in oocytes. J Cell Biol. 2016; 215: 611-619.

[2]	Tanenbaum ME, Medema RH. Mechanisms of centrosome separation and bipolar spindle assembly. Dev Cell. 2010; 19: 797-806.

[3]	Maiato H, Logarinho E. Mitotic spindle multipolarity without centrosome amplification. Nat Cell Biol. 2014; 16: 386-394.

[4]	Webster A, Schuh M. Mechanisms of aneuploidy in human eggs. Trends Cell Biol. 2017; 27: 55-68.

[5]	Wu T, Dong J, Fu J, et al. The mechanism of acentrosomal spindle assembly in human oocytes. Science. 2022; 378(6621): eabq7361.

[6]	Wu T, Luo Y, Zhang M, et al. Mechanisms of minor pole–mediated spindle bipolarization in human oocytes. Science. 2024; 385: eado1022.

[7]	Sedó CA, Schatten H, Combelles CM, Rawe VY. The nuclear mitotic apparatus (NuMA) protein: localization and dynamics in human oocytes, fertilization and early embryos. Mol Hum Reprod. 2011; 17: 392-398.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.