NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice
Shi-Qing Li , Ya-Ru Wang , Zhong-Liang Xie , Yan Wang , Zi-Han Feng , Jian-Hao Xu , Bing Yuan , Yi-Tong Zhang , Guan Yang , Jing-Lin Wang , Yuan Yuan
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70099
NLRP3 activation maintains intestinal epithelial barrier and reduces liver injury in alcoholic liver disease mice
| •Activation of the NLRP3-GSDMD pathway in the ileum of Alcoholic liver disease (ALD) mice. | |
•NLRP3 activation maintains homeostasis of gut microbiota and intestinal epithelial barrier in ALD mice. | |
•ALD mice infected with V. vulnificus infection exhibited no further activation of NLRP3 in the ileum, leading to increased intestinal permeability and bloodstream infections. |
alcoholic liver disease / intestinal epithelial barrier / NLRP3 inflammasome / Vibrio infection
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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