The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome

Lan Luo; Xiaoli Zhuang; Lin Fu; Ziyuan Dong; Shuyuan Yi; Kan Wang; Yu Jiang; Ju Zhao; Xiaofang Yang; Feilong Hei

doi:10.1002/ctm2.70098

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70098 DOI: 10.1002/ctm2.70098

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The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome

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Abstract

	•NLRP3 inflammasome activation is pivotal in mediating the excessive inflammatory response in ALI/ARDS.
	•Glycolytic reprogramming regulates NLRP3 inflammasome activation.
	•Therapeutic potential of targeting glycolytic reprogramming to inhibit NLRP3 inflammasome activation in ALI/ARDS.

Keywords

acute lung injury/acute respiratory distress syndrome / glycolytic reprogramming,macrophage / NLRP3 inflammasome

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Lan Luo,Xiaoli Zhuang,Lin Fu,Ziyuan Dong,Shuyuan Yi,Kan Wang,Yu Jiang,Ju Zhao,Xiaofang Yang,Feilong Hei. The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury/acute respiratory distress syndrome. Clinical and Translational Medicine, 2024, 14(12): e70098 DOI:10.1002/ctm2.70098

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.