Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof-of-concept study
Perrine Burdeyron , Sébastien Giraud , Maryne Lepoittevin , Nina Jordan , Sonia Brishoual , Maïté Jacquard , Virginie Ameteau , Nadège Boildieu , Estelle Lemarie , Jonathan Daniel , Frédéric Martins , Nicolas Mélis , Marine Coué , Raphaël Thuillier , Henri Leuvenink , Luc Pellerin , Thierry Hauet , Clara Steichen
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (12) : e70095
Dynamic conditioning of porcine kidney grafts with extracellular vesicles derived from urine progenitor cells: A proof-of-concept study
•UPCs from porcine urine can be used to generate a cell therapy product based on extracellular vesicles (pUPC-EVs). | |
•pUPC-EVs injection during HMP and NMP decreases cell damage markers and has an immunomodulatory effect. | |
•pUPC-EVs-treated kidneys have distinct biochemical, metabolic, and transcriptomic profiles highlighting targets of interest. | |
•Our results pave the way for combining machine perfusion with EV-based cell therapy for kidney conditioning. |
cell therapy / exosomes / extracellular vesicles / kidney preservation / kidney transplantation / machine perfusion / preclinical porcine model / urine progenitor/stem cells
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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