Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single-cell transcriptomics

Jialin Wang , Xuejing Li , Jing Guo , Zan Yuan , Xinyu Tong , Zehao Xiao , Meng Liu , Changxiaofeng Liu , Hongyun Wang , Lei Gong , Chuzhong Li , Yazhuo Zhang , Weiyan Xie , Chunhui Liu

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e70090

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e70090 DOI: 10.1002/ctm2.70090
RESEARCH ARTICLE

Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single-cell transcriptomics

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Abstract

•The first-ever visualization of cellular distributions in normal and tumor pituitary tissues.

•The inter-and intra-tumoral transcriptomic heterogeneity of somatotroph PitNETs was comprehensively revealed.

•Identification of potential protumor factors and critical signaling pathways, opening new avenues for therapeutic intervention.

Keywords

somatotroph PitNETs / spatial transcriptomics / single-cell RNA sequencing / tumour heterogeneity

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Jialin Wang,Xuejing Li,Jing Guo,Zan Yuan,Xinyu Tong,Zehao Xiao,Meng Liu,Changxiaofeng Liu,Hongyun Wang,Lei Gong,Chuzhong Li,Yazhuo Zhang,Weiyan Xie,Chunhui Liu. Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single-cell transcriptomics. Clinical and Translational Medicine, 2024, 14(11): e70090 DOI:10.1002/ctm2.70090

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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