Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single-cell transcriptomics
Jialin Wang , Xuejing Li , Jing Guo , Zan Yuan , Xinyu Tong , Zehao Xiao , Meng Liu , Changxiaofeng Liu , Hongyun Wang , Lei Gong , Chuzhong Li , Yazhuo Zhang , Weiyan Xie , Chunhui Liu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e70090
Comprehensive mapping of somatotroph pituitary neuroendocrine tumour heterogeneity using spatial and single-cell transcriptomics
•The first-ever visualization of cellular distributions in normal and tumor pituitary tissues. | |
•The inter-and intra-tumoral transcriptomic heterogeneity of somatotroph PitNETs was comprehensively revealed. | |
•Identification of potential protumor factors and critical signaling pathways, opening new avenues for therapeutic intervention. |
somatotroph PitNETs / spatial transcriptomics / single-cell RNA sequencing / tumour heterogeneity
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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