Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn’s disease

Abstract

	•Extracellular vesicles (EVs) of creeping fat (CrF) derived adipose stem cells effectively attenuate chronic mesenteritis and colitis in Crohn’s disease (CD).
	•The lymphatic vessels play an important role in disease development of CD and their functions are improved by CrF-EV-miR-132-3p through RASA1/ERK1/2 signaling.
	•MiR-132-3p expression is upregulated in CrF and serum of CD patients, and tightly linked with inflammation and disease activity.

Keywords

adipose-derived stem cells / creeping fat / Crohn’s disease / extracellular vesicle / lymphatic function

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.