Interferon regulatory factor 5 suppresses epithelial-to-mesenchymal transition and metastasis by inducing GATA2 expression in colorectal cancer

Teng Pan; Zaoqu Liu; Xue Feng; Deyu zhang; Lifeng Li; Yu Song; Qi Luo; Xiaojin Luo; Xiaohang Chen; Yao Yao; Guanglin Zhou; Jose M Vicencio; Weilong Zhang; Mingzhu Yin; Dan Wang; Jinhai Deng; Xuerui Tan; Fengxiang Wei

doi:10.1002/ctm2.70077

Clinical and Translational Medicine ›› 2025, Vol. 15 ›› Issue (3) : e70077 DOI: 10.1002/ctm2.70077

LETTER TO THE JOURNAL

Interferon regulatory factor 5 suppresses epithelial-to-mesenchymal transition and metastasis by inducing GATA2 expression in colorectal cancer

Teng Pan ¹
, Zaoqu Liu ²
, Xue Feng ³
, Deyu zhang ⁴
, Lifeng Li ⁵
, Yu Song ⁶
, Qi Luo ⁷
, Xiaojin Luo ⁸
, Xiaohang Chen ⁸
, Yao Yao ⁸^,⁹
, Guanglin Zhou ¹
, Jose M Vicencio ¹⁰
, Weilong Zhang ¹¹
, Mingzhu Yin ¹²
, Dan Wang ¹³
, Jinhai Deng ¹³^,¹²^,^†
, Xuerui Tan ¹⁴^,¹⁵^,¹⁶^,¹⁷^,^†
, Fengxiang Wei ¹^,⁸^,⁹^,^†

Author information +

¹. Institute of Maternal and Child Medical Research, Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, China

². Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

³. Department of Respiratory and Critical Care Medicine, Tianjin Chest Hospital, Tianjin, People’s Republic of China

⁴. Department of Gastroenterology, Changhai Hospital, Shanghai, China

⁵. Cancer center, Internet Medical and System Applications of National Engineering Laboratory, Zhengzhou, China

⁶. Department of Otolaryngology, Head & Neck Surgery Peking University First Hospital, Beijing, China

⁷. School of Basic Medical Sciences, Jiamusi University, Jiamusi, China

⁸. The Genetics Laboratory, Longgang District Maternity and Child Healthcare Hospital of Shenzhen City, Shenzhen, China

⁹. Institute of Maternal and Child Medical Research, Longgang Maternity and Child Institute of Shantou University Medical College, Shenzhen, China

¹⁰. Cancer Institute, Paul O’Gorman Building, University College London, London, UK

¹¹. Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China

¹². Clinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC), Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University,Wanzhou, China

¹³. Richard Dimbleby Laboratory of Cancer Research, Randall Division and Division of Cancer and Pharmaceutical Sciences, King’s College London, London, UK

¹⁴. Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Shantou, China

¹⁵. Human Phenome Institute, Shantou University Medical College, Shantou, China

¹⁶. Human Phenome Institute, Guangdong Engineering Research Center of Human Phenome, Shantou, China

¹⁷. Clinical Medical Research Center, First Affiliated Hospital of Shantou University Medical College, Shantou, China

jinhaideng_kcl@163.com

xutanfrankly@yahoo.com.cn

haowei727499@163.com

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Teng Pan, Zaoqu Liu, Xue Feng, Deyu zhang, Lifeng Li, Yu Song, Qi Luo, Xiaojin Luo, Xiaohang Chen, Yao Yao, Guanglin Zhou, Jose M Vicencio, Weilong Zhang, Mingzhu Yin, Dan Wang, Jinhai Deng, Xuerui Tan, Fengxiang Wei. Interferon regulatory factor 5 suppresses epithelial-to-mesenchymal transition and metastasis by inducing GATA2 expression in colorectal cancer. Clinical and Translational Medicine, 2025, 15(3): e70077 DOI:10.1002/ctm2.70077

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References

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.