Genetic variants explain ancestry-related differences in type 2 diabetes risk

Aaron J. Deutsch; Kirk Smith; Miriam S. Udler

doi:10.1002/ctm2.70076

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e70076 DOI: 10.1002/ctm2.70076

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Genetic variants explain ancestry-related differences in type 2 diabetes risk

Aaron J. Deutsch ¹^,²^,³^,⁴
, Kirk Smith ¹^,²^,³
, Miriam S. Udler ¹^,²^,³^,⁴^,^†

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Aaron J. Deutsch, Kirk Smith, Miriam S. Udler. Genetic variants explain ancestry-related differences in type 2 diabetes risk. Clinical and Translational Medicine, 2024, 14(11): e70076 DOI:10.1002/ctm2.70076

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References

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[6]	Kim H, Westerman KE, Smith K, et al. High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease. Diabetologia. 2023;66(3):495-507.

[7]	Smith K, Deutsch AJ, McGrail C, et al. Multi-ancestry polygenic mechanisms of type 2 diabetes. Nat Med. 2024;30(4):1065-1074.

[8]	Yaghootkar H, Scott RA, White CC, et al. Genetic evidence for a normal-weight “metabolically obese” phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes. 2014;63(12):4369-4377.

[9]	WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363(9403):157-163.

[10]	Yaghootkar H, Whitcher B, Bell JD, Thomas EL. Ethnic differences in adiposity and diabetes risk-insights from genetic studies. J Intern Med. 2020;288(3):271-283.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.