Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials

Abstract

	•Lactylation significantly influences tumour metabolism and gene regulation, contributing to cancer progression.
	•Advanced sequencing and machine learning reveal widespread lactylation sites in tumours.
	•Targeting lactylation enzymes shows promise in enhancing anti-tumour drug efficacy and overcoming chemotherapy resistance.
	•This review outlines the clinical implications and future research directions of lactylation in oncology.

Keywords

clinical translation / lactylation / post translational modification / tumour biology / tumour microenvironment

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