Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials

Yipeng He; Tianbao Song; Jinzhuo Ning; Zefeng Wang; Zhen Yin; Pengcheng Jiang; Qin Yuan; Weimin Yu; Fan Cheng

doi:10.1002/ctm2.70070

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (11) : e70070 DOI: 10.1002/ctm2.70070

REVIEW

Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials

Author information +

History +

PDF

Abstract

	•Lactylation significantly influences tumour metabolism and gene regulation, contributing to cancer progression.
	•Advanced sequencing and machine learning reveal widespread lactylation sites in tumours.
	•Targeting lactylation enzymes shows promise in enhancing anti-tumour drug efficacy and overcoming chemotherapy resistance.
	•This review outlines the clinical implications and future research directions of lactylation in oncology.

Keywords

clinical translation / lactylation / post translational modification / tumour biology / tumour microenvironment

Cite this article

Download citation ▾

Yipeng He,Tianbao Song,Jinzhuo Ning,Zefeng Wang,Zhen Yin,Pengcheng Jiang,Qin Yuan,Weimin Yu,Fan Cheng. Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials. Clinical and Translational Medicine, 2024, 14(11): e70070 DOI:10.1002/ctm2.70070

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

RIGHTS & PERMISSIONS

2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.