Single-cell transcriptome analysis reveals evolving tumour microenvironment induced by immunochemotherapy in nasopharyngeal carcinoma
Yaofei Jiang , Weixin Bei , Wangzhong Li , Ying Huang , Shuiqing He , Xiaobin Zhu , Lisheng Zheng , Weixiong Xia , Shuhui Dong , Qin Liu , Chuanrun Zhang , Shuhui Lv , Changqing Xie , Yanqun Xiang , Guoying Liu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70061
Single-cell transcriptome analysis reveals evolving tumour microenvironment induced by immunochemotherapy in nasopharyngeal carcinoma
•Immunochemotherapy remodeled T cell phenotypes. | |
•For the patients achieving complete response, more interferon gamma was provided by CD8+ T cells after therapy, which would be the key for TAMs pro-inflammatory repolarization and eventually promote the CD8+ T cells maturation in turns. | |
•Among patients who did not reach complete response, malignant cells exhibited higher level of immune checkpoint genes before therapy, and decreased tumor antigen presentation activity, which may underlie the resistance mechanism to therapy. |
immunochemotherapy effect / nasopharyngeal carcinoma / scRNA-seq / tumour microenvironment
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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