CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma

Yueqi Wang; Shengli Li; Xiaobo Bo; Yuan Li; Changcheng Wang; Lingxi Nan; Dexiang Zhang; Houbao Liu; Jiwei Zhang

doi:10.1002/ctm2.70060

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70060 DOI: 10.1002/ctm2.70060

RESEARCH ARTICLE

CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma

Yueqi Wang ¹^,²^,³
, Shengli Li ⁴^,^†
, Xiaobo Bo ¹^,²^,³
, Yuan Li ⁵
, Changcheng Wang ¹^,²^,³
, Lingxi Nan ¹^,²^,³
, Dexiang Zhang ⁶
, Houbao Liu ¹^,²^,³^,⁶^,^†
, Jiwei Zhang ⁵^,^†

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Abstract

	•We present a comprehensive characterisation of circRNA landscape in gallbladder carcinoma (GBC).
	•CircAATF is positively associated with CD4⁺ T cell abundance and PD-L1 expression and is shown to promote PD-L1 treatment in mouse model.
	•CircAATF can elevate PD-L1 level through phosphorylated AKT and linear AATF, which upregulates PD-L1 by acting as a sponge of miR-142-5p.

Keywords

circular RNA / gallbladder carcinoma / immunotherapy / PD-L1 / tumour immunology

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Yueqi Wang,Shengli Li,Xiaobo Bo,Yuan Li,Changcheng Wang,Lingxi Nan,Dexiang Zhang,Houbao Liu,Jiwei Zhang. CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma. Clinical and Translational Medicine, 2024, 14(10): e70060 DOI:10.1002/ctm2.70060

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.