Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4

Wenbo Sun; Kenny Xu; Xiao Li; Peipei Qian; Fan Xu; Yanyan Zhang; Xiumei Wang; Zhi Xu; Jiaji Ding; Xinyu Xu; Xiaowei Wei; Qin Jiang; Yong Xu

doi:10.1002/ctm2.70058

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70058 DOI: 10.1002/ctm2.70058

RESEARCH ARTICLE

Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4

Wenbo Sun ¹^,²^,³
, Kenny Xu ⁴
, Xiao Li ²
, Peipei Qian ¹^,²
, Fan Xu ¹^,²
, Yanyan Zhang ²
, Xiumei Wang ¹^,⁵
, Zhi Xu ¹
, Jiaji Ding ²
, Xinyu Xu ²
, Xiaowei Wei ⁵
, Qin Jiang ¹^,^†
, Yong Xu ¹^,²^,⁶^,⁷^,^†

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Abstract

	•RelB activates inflammatory signalling by upregulating IL-8 and suppressing AR.
	•RelB upregulates S100A4 by cooperating with NFATC1.
	•IL-8 boosts EMT by activating Snail 1 and Twist 1, and S100A4 exacerbates osteolytic metastasis via calcium consumption.
	•RelB harnesses IL-8 and S100A4 to drive PCa osteolytic metastasis.

Keywords

IL-8 / osteolytic metastasis / prostate cancer / RelB / S100A4

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Wenbo Sun,Kenny Xu,Xiao Li,Peipei Qian,Fan Xu,Yanyan Zhang,Xiumei Wang,Zhi Xu,Jiaji Ding,Xinyu Xu,Xiaowei Wei,Qin Jiang,Yong Xu. Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4. Clinical and Translational Medicine, 2024, 14(10): e70058 DOI:10.1002/ctm2.70058

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.