Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4
Wenbo Sun , Kenny Xu , Xiao Li , Peipei Qian , Fan Xu , Yanyan Zhang , Xiumei Wang , Zhi Xu , Jiaji Ding , Xinyu Xu , Xiaowei Wei , Qin Jiang , Yong Xu
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70058
Insight into prostate cancer osteolytic metastasis by RelB coordination of IL-8 and S100A4
•RelB activates inflammatory signalling by upregulating IL-8 and suppressing AR. | |
•RelB upregulates S100A4 by cooperating with NFATC1. | |
•IL-8 boosts EMT by activating Snail 1 and Twist 1, and S100A4 exacerbates osteolytic metastasis via calcium consumption. | |
•RelB harnesses IL-8 and S100A4 to drive PCa osteolytic metastasis. |
IL-8 / osteolytic metastasis / prostate cancer / RelB / S100A4
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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