Evolution of aberrant brain-wide spatiotemporal dynamics of resting-state networks in a Huntington’s disease mouse model

Abstract

	•Hyperactivity in the LCN-linked regions within short QPPs observed before motor impairment onset.
	•DMLN QPP presents a progressive decrease in DMLN activity and occurrence along HD-like phenotype development.
	•Breakdown of the LCN DMLN state flux at motor onset leads to a subsequent absence of the LCN DMLN QPP at an advanced HD-like stage.

Keywords

astrocytes / biomarkers / Huntington’s disease / large-scale brain networks / neurodegeneration / pericytes / quasi-periodic patterns / resting-state fMRI / VEGF

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