Mesenchymal stem cells with an enhanced antioxidant capacity integrate as smoothmuscle cells in amodel of diabetic detrusor underactivity

Chae-Min Ryu , Yong Hwan Kim , Jung-Hyun Shin , Seungun Lee , Hyein Ju , Yun Ji Nam , Hyungu Kwon , Min-Young Jo , Jinah Lee , Hyun Jun Im , Min Gi Jang , Ki-Sung Hong , Hyung-Min Chung , Sang Hoon Song , Myung-Soo Choo , Seong Who Kim , Juhyun Park , Dong-Myung Shin

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70052

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70052 DOI: 10.1002/ctm2.70052
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Mesenchymal stem cells with an enhanced antioxidant capacity integrate as smoothmuscle cells in amodel of diabetic detrusor underactivity

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Chae-Min Ryu, Yong Hwan Kim, Jung-Hyun Shin, Seungun Lee, Hyein Ju, Yun Ji Nam, Hyungu Kwon, Min-Young Jo, Jinah Lee, Hyun Jun Im, Min Gi Jang, Ki-Sung Hong, Hyung-Min Chung, Sang Hoon Song, Myung-Soo Choo, Seong Who Kim, Juhyun Park, Dong-Myung Shin. Mesenchymal stem cells with an enhanced antioxidant capacity integrate as smoothmuscle cells in amodel of diabetic detrusor underactivity. Clinical and Translational Medicine, 2024, 14(10): e70052 DOI:10.1002/ctm2.70052

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References

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van Koeveringe GA, Vahabi B, Andersson KE, Kirschner-Herrmans R, Oelke M. Detrusor underactivity: a plea for new approaches to a common bladder dysfunction. Neurourol Urodyn. 2011; 30: 723-728.

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Marti-Chillon GJ, Muntion S, Preciado S, et al. Therapeutic potential of mesenchymal stromal/stem cells in critical-care patients with systemic inflammatory response syndrome. Clin Transl Med. 2023; 13: e1163.

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Yu HY, Lee S, Ju H, et al. Intravital imaging and single cell transcriptomic analysis for engraftment of mesenchymal stem cells in an animal model of interstitial cystitis/bladder pain syndrome. Biomaterials. 2022; 280: 121277.

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Shin JH, Ryu CM, Ju H, et al. Therapeutic efficacy of human embryonic stem cell-derived multipotent stem/stromal cells in diabetic detrusor underactivity: a preclinical study. J Clin Med. 2020; 9:2853.

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Shin JH, Ryu CM, Ju H, et al. Synergistic effects of N-acetylcysteine and mesenchymal stem cell in a lipopolysaccharide-induced interstitial cystitis rat model. Cells. 2019; 9: 86.

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Jeong EM, Yoon JH, Lim J, et al. Real-time monitoring of glutathione in living cells reveals that high glutathione levels are required to maintain stem cell function. Stem Cell Rep. 2018; 10: 600-614.

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Lim J, Heo J, Ju H, et al. Glutathione dynamics determine the therapeutic efficacy of mesenchymal stem cells for graft-versus-host disease via CREB1-NRF2 pathway. Sci Adv. 2020; 6: eaba1334.

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Lim J, Heo J, Yu HY, et al. Small-sized mesenchymal stem cells with high glutathione dynamics show improved therapeutic potency in graft-versus-host disease. Clin Transl Med. 2021; 11: e476.

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Ju H, Yun H, Kim Y, et al. Activating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation. Exp Mol Med. 2023; 55: 413-425.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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