BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively

Cong-Rong Li; Shi-Ya Xie; Shu-Ping Zhang; Yan-Jie Yang; Li-Li Yang; Ying Cao; Li-Li Wang; Feng-Yu Zhu; Ruo-Lei Wang; Zhi-Xia Yang; Chen-Chen Cui; Yan-Ru Li; Jia-Ning Xu; Feng Yue; Pei-Zhe Tian; Qian Wang; Hong-Jie Yao; Yi-Chun Guan; Shao-Di Zhang; Xiao-Yan Ying; Dong Zhang; Cui-Lian Zhang

doi:10.1002/ctm2.70051

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70051 DOI: 10.1002/ctm2.70051

LETTER TO THE JOURNAL

BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively

Cong-Rong Li ¹^,²^,³^,⁴
, Shi-Ya Xie ¹^,²^,³^,⁴
, Shu-Ping Zhang ¹^,²^,³^,⁴
, Yan-Jie Yang ¹^,²^,³^,⁴
, Li-Li Yang ⁵
, Ying Cao ⁵
, Li-Li Wang ²
, Feng-Yu Zhu ²
, Ruo-Lei Wang ²
, Zhi-Xia Yang ¹
, Chen-Chen Cui ⁶
, Yan-Ru Li ⁶
, Jia-Ning Xu ⁶
, Feng Yue ⁶
, Pei-Zhe Tian ⁶
, Qian Wang ⁶
, Hong-Jie Yao ⁷
, Yi-Chun Guan ⁸
, Shao-Di Zhang ⁶^,^†
, Xiao-Yan Ying ⁵^,^†
, Dong Zhang ¹^,²^,³^,⁴^,^†
, Cui-Lian Zhang ⁶^,^†

Author information +

¹. Department of Gynaecology and Obstetrics, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

². State Key Lab of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu, China

³. NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China

⁴. Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People’s Republic of China, Hefei, Anhui, China

⁵. Department of Gynaecology and Obstetrics, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

⁶. Reproductive Medical Center, Henan Provincial People’s Hospital & People’s Hospital of Zhengzhou University, Zhengzhou, Henan, China

⁷. Guangzhou National Laboratory, University of Chinese Academy of Sciences, Guangzhou, Guangdong, China

⁸. Center for Reproductive Medicine, the Third Affiliate Hospital of Zhengzhou University, Zhengzhou, Henan, China

zhangshd@126.com

xiaoyanying_cool@163.com

dong.ray.zhang@ahmu.edu.cn

luckyzcl@qq.com

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Cong-Rong Li,Shi-Ya Xie,Shu-Ping Zhang,Yan-Jie Yang,Li-Li Yang,Ying Cao,Li-Li Wang,Feng-Yu Zhu,Ruo-Lei Wang,Zhi-Xia Yang,Chen-Chen Cui,Yan-Ru Li,Jia-Ning Xu,Feng Yue,Pei-Zhe Tian,Qian Wang,Hong-Jie Yao,Yi-Chun Guan,Shao-Di Zhang,Xiao-Yan Ying,Dong Zhang,Cui-Lian Zhang. BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively. Clinical and Translational Medicine, 2024, 14(10): e70051 DOI:10.1002/ctm2.70051

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.