Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity

Abstract

	•High-fat-diet-induced obesity aggravate the progression of TMJ OA in mice.
	•Obese adipose tissue participates in cartilage damage through the altered miRNA in extracellular vesicles.
	•Inhibition of miR-3074-5p/SMAD4 pathway in chondrocyte alleviated the effect of HFD-EVs on TMJ OA.

Keywords

adipose tissue-derived extracellular vesicles / geranylgeranyl diphosphate synthase / miR-3074-5p / temporomandibular joint osteoarthritis

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.