Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity

Baochao Li; Yuqin Jin; Bingqing Zhang; Tong Lu; Jialing Li; Jingzi Zhang; Yiwen Zhou; Yanyi Wang; Caixia Zhang; Yue Zhao; Huang Li

doi:10.1002/ctm2.70029

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (10) : e70029 DOI: 10.1002/ctm2.70029

RESEARCH ARTICLE

Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity

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Abstract

	•High-fat-diet-induced obesity aggravate the progression of TMJ OA in mice.
	•Obese adipose tissue participates in cartilage damage through the altered miRNA in extracellular vesicles.
	•Inhibition of miR-3074-5p/SMAD4 pathway in chondrocyte alleviated the effect of HFD-EVs on TMJ OA.

Keywords

adipose tissue-derived extracellular vesicles / geranylgeranyl diphosphate synthase / miR-3074-5p / temporomandibular joint osteoarthritis

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Baochao Li, Yuqin Jin, Bingqing Zhang, Tong Lu, Jialing Li, Jingzi Zhang, Yiwen Zhou, Yanyi Wang, Caixia Zhang, Yue Zhao, Huang Li. Adipose tissue-derived extracellular vesicles aggravate temporomandibular joint osteoarthritis associated with obesity. Clinical and Translational Medicine, 2024, 14(10): e70029 DOI:10.1002/ctm2.70029

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.