IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS

Shi Zhang; Wei Huang; Xueling Wu; Hanbing Chen; Lu Wang; Jie Chao; Jianfeng Xie; Haibo Qiu

doi:10.1002/ctm2.70027

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70027 DOI: 10.1002/ctm2.70027

RESEARCH ARTICLE

IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS

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Abstract

	In monocytes and macrophages, the endogenous double-stranded RNA, IFIH1-binding RNA 1 (IBR1), binds to the helicase domain of IFIH1 because of its unique double-stranded structure.
	IBR1 plays a significant role in macrophage polarisation and the development of acute respiratory distress syndrome (ARDS) induced by Gram-negative bacteria or lipopolysaccharide (LPS).
	Administration of IFIH1 variants has potential for eliminating pulmonary IBR1 and reducing inflammatory lung injury in ARDS patients.

Keywords

ARDS / dsRNA / IFIH1 / novel transcript

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Shi Zhang,Wei Huang,Xueling Wu,Hanbing Chen,Lu Wang,Jie Chao,Jianfeng Xie,Haibo Qiu. IBR1, a novel endogenous IFIH1-binding dsRNA, governs IFIH1 activation and M1 macrophage polarisation in ARDS. Clinical and Translational Medicine, 2024, 14(9): e70027 DOI:10.1002/ctm2.70027

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.