The emerging roles of UFMylation in the modulation of immune responses
Zhengyan Liang , Rongxuan Ning , Zhaoxiang Wang , Xia Kong , Yubin Yan , Yafei Cai , Zhiwei He , Xin-guang Liu , Yongkang Zou , Junzhi Zhou
Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70019
The emerging roles of UFMylation in the modulation of immune responses
Post-translational modification is a rite of passage for cellular functional proteins and ultimately regulate almost all aspects of life. Ubiquitin-fold modifier 1 (UFM1) system represents a newly identified ubiquitin-like modification system with indispensable biological functions, and the underlying biological mechanisms remain largely undiscovered. The field has recently experienced a rapid growth of research revealing that UFMylation directly or indirectly regulates multiple immune processes. Here, we summarised important advances that how UFMylation system responds to intrinsic and extrinsic stresses under certain physiological or pathological conditions and safeguards immune homeostasis, providing novel perspectives into the regulatory framework and functions of UFMylation system, and its therapeutic applications in human diseases.
immune homeostasis / post-translational modifications / UFM1 / UFMylation
2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
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