Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages

Abstract

	•Human border region macrophages are distinct from microglia.
	•These distinct phenotypes are established early during embryonal development - Brain border macrophages are partially replaced by bone marrow-derived myeloid cells.
	•The transcriptional phenotypes of glioblastoma-associated macrophage are determined by the anatomical region.

Keywords

brain border regions / development / glioblastoma / immunity / macrophage / turnover

References

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RIGHTS & PERMISSIONS

2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.