Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages

Patrick Süß; Martin Diebold; Roman Sankowski

doi:10.1002/ctm2.70014

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70014 DOI: 10.1002/ctm2.70014

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Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages

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Abstract

	•Human border region macrophages are distinct from microglia.
	•These distinct phenotypes are established early during embryonal development - Brain border macrophages are partially replaced by bone marrow-derived myeloid cells.
	•The transcriptional phenotypes of glioblastoma-associated macrophage are determined by the anatomical region.

Keywords

brain border regions / development / glioblastoma / immunity / macrophage / turnover

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Patrick Süß, Martin Diebold, Roman Sankowski. Advances in understanding the immunity of the brain and its borders: Focus on brain macrophages. Clinical and Translational Medicine, 2024, 14(9): e70014 DOI:10.1002/ctm2.70014

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.