Ecological and evolutionary dynamics to design and improve ovarian cancer treatment

Grace Y. Q. Han; Monica Alexander; Julia Gattozzi; Marilyn Day; Elayna Kirsch; Narges Tafreshi; Raafat Chalar; Soraya Rahni; Gabrielle Gossner; William Burke; Mehdi Damaghi

doi:10.1002/ctm2.70012

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70012 DOI: 10.1002/ctm2.70012

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Ecological and evolutionary dynamics to design and improve ovarian cancer treatment

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Abstract

	•Tumours are ecosystems in which cancer and non-cancer cells interact and evolve in complex and dynamic ways.
	•Conventional therapies for ovarian cancer inevitably lead to the development of resistance because they fail to consider tumours’ heterogeneity and cellular plasticity.
	•Eco-evolutionarily designed therapies should consider cancer cell plasticity and patient-specific characteristics to improve clinical outcome and prevent relapse.

Keywords

ovarian cancer / phenotypic plasticity / tumour ecology / tumour evolution / tumour microenvironment

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Grace Y. Q. Han, Monica Alexander, Julia Gattozzi, Marilyn Day, Elayna Kirsch, Narges Tafreshi, Raafat Chalar, Soraya Rahni, Gabrielle Gossner, William Burke, Mehdi Damaghi. Ecological and evolutionary dynamics to design and improve ovarian cancer treatment. Clinical and Translational Medicine, 2024, 14(9): e70012 DOI:10.1002/ctm2.70012

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.