Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial

Lin Wan; Huan Wang; Yan Liang; Xun Zhang; Xinyun Yao; Gang Zhu; Jun Cai; Guoyin Liu; Xinting Liu; Qianqian Niu; Siwen Li; Bo Zhang; Jing Gao; Jing Wang; Xiuyu Shi; Linyan Hu; Xiaoyan Liu; Zhiyong Zou; Guang Yang

doi:10.1002/ctm2.70006

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70006 DOI: 10.1002/ctm2.70006

LETTER TO THE JOURNAL

Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial

Lin Wan ¹^,²
, Huan Wang ³
, Yan Liang ¹^,²
, Xun Zhang ⁴
, Xinyun Yao ¹^,²
, Gang Zhu ¹^,²
, Jun Cai ⁵
, Guoyin Liu ¹^,²
, Xinting Liu ¹^,²
, Qianqian Niu ¹^,²
, Siwen Li ¹^,²
, Bo Zhang ⁶
, Jing Gao ¹^,²
, Jing Wang ¹^,²
, Xiuyu Shi ¹^,²
, Linyan Hu ¹^,²
, Xiaoyan Liu ⁷
, Zhiyong Zou ³
, Guang Yang ¹^,²^,⁸^,^†

Author information +

¹. Senior Department of Pediatrics, The Seventh Medical Centre of PLA General Hospital, Beijing, China

². Department of Pediatrics, The First Medical Centre, Chinese PLA General Hospital, Beijing, China

³. National Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China

⁴. Department of Pharmacy, PLA General Hospital, Beijing, China

⁵. Hypertension Centre, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China

⁶. Department of Neurology and ICCTR Biostatistics and Research Design Centre, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

⁷. Heart Centre and Beijing Key Laboratory of Hypertension, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

⁸. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China

yangg301@126.com

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Lin Wan, Huan Wang, Yan Liang, Xun Zhang, Xinyun Yao, Gang Zhu, Jun Cai, Guoyin Liu, Xinting Liu, Qianqian Niu, Siwen Li, Bo Zhang, Jing Gao, Jing Wang, Xiuyu Shi, Linyan Hu, Xiaoyan Liu, Zhiyong Zou, Guang Yang. Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial. Clinical and Translational Medicine, 2024, 14(9): e70006 DOI:10.1002/ctm2.70006

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References

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[1]	Dan Z, Mao X, Liu Q, et al. Altered gut microbial profile is associated with abnormal metabolism activity of autism spectrum disorder. Gut Microbes. 2020; 11(5): 1246–1267.

[2]	Lou M, Cao A, Jin C, et al. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. Gut. 2022; 71(8): 1588–1599.

[3]	Yap CX, Henders AK, Alvares GA, et al. Autism-related dietary preferences mediate autism-gut microbiome associations. Cell. 2021; 184(24): 5916–5931. e17.

[4]	Kang DW, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017; 5(1): 10.

[5]	Li N, Chen H, Cheng Y, et al. Fecal microbiota transplantation relieves gastrointestinal and autism symptoms by improving the gut microbiota in an open-label study. Front Cell Infect Microbiol. 2021; 11: 759435.

[6]	Zhang Y, Zhang J, Pan Z, et al. Effects of washed fecal bacteria transplantation in sleep quality, stool features and autism symptomatology: a chinese preliminary observational study. Neuropsychiatr Dis Treat. 2022; 18: 1165–1173.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.