Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial

Lin Wan , Huan Wang , Yan Liang , Xun Zhang , Xinyun Yao , Gang Zhu , Jun Cai , Guoyin Liu , Xinting Liu , Qianqian Niu , Siwen Li , Bo Zhang , Jing Gao , Jing Wang , Xiuyu Shi , Linyan Hu , Xiaoyan Liu , Zhiyong Zou , Guang Yang

Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70006

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Clinical and Translational Medicine ›› 2024, Vol. 14 ›› Issue (9) : e70006 DOI: 10.1002/ctm2.70006
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Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial

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Lin Wan, Huan Wang, Yan Liang, Xun Zhang, Xinyun Yao, Gang Zhu, Jun Cai, Guoyin Liu, Xinting Liu, Qianqian Niu, Siwen Li, Bo Zhang, Jing Gao, Jing Wang, Xiuyu Shi, Linyan Hu, Xiaoyan Liu, Zhiyong Zou, Guang Yang. Effect of oral faecalmicrobiota transplantation intervention for children with autism spectrum disorder: A randomised, double-blind, placebo-controlled trial. Clinical and Translational Medicine, 2024, 14(9): e70006 DOI:10.1002/ctm2.70006

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References

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Dan Z, Mao X, Liu Q, et al. Altered gut microbial profile is associated with abnormal metabolism activity of autism spectrum disorder. Gut Microbes. 2020; 11(5): 1246–1267.

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Lou M, Cao A, Jin C, et al. Deviated and early unsustainable stunted development of gut microbiota in children with autism spectrum disorder. Gut. 2022; 71(8): 1588–1599.

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Yap CX, Henders AK, Alvares GA, et al. Autism-related dietary preferences mediate autism-gut microbiome associations. Cell. 2021; 184(24): 5916–5931. e17.

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Kang DW, Adams JB, Gregory AC, et al. Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study. Microbiome. 2017; 5(1): 10.

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Li N, Chen H, Cheng Y, et al. Fecal microbiota transplantation relieves gastrointestinal and autism symptoms by improving the gut microbiota in an open-label study. Front Cell Infect Microbiol. 2021; 11: 759435.

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Zhang Y, Zhang J, Pan Z, et al. Effects of washed fecal bacteria transplantation in sleep quality, stool features and autism symptomatology: a chinese preliminary observational study. Neuropsychiatr Dis Treat. 2022; 18: 1165–1173.

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

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