Single-cell multi-modal chromatin profiles revealing epigenetic regulations of cells in hepatocellular carcinoma

Abstract

	•scCPA-Tag offers a highly efficient and high throughput technique to simultaneously profile histone modification and chromatin accessibility within a single cell.
	•scCPA-Tag enables to uncover multiple epigenetic modification features of cellular compositions within tumor tissues.
	•scCPA-Tag facilitates the exploration of the epigenetic landscapes of heterogeneous cell types and provides the mechanisms governing gene expression regulation.

Keywords

chromatin accessibility / epigenomics / hepatocellular carcinoma / histone modifications / multiomics / single-cell sequencing

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2024 The Author(s). Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.